Síndrome de tracción vitreorretiniana

César Atencia, Hernán Ríos, Francisco J. Rodríguez


La Tracción vitreomacular (TVM) hace parte de un grupo de trastornos que
se cree tienen una génesis similar, y teniendo en cuenta las variaciones de la
terminología en la literatura, es fundamental tener claridad sobre los conceptos
básicos, por tal motivo se realiza un artículo de revisión de literatura donde se
describe la historia, defi nición, clasifi cación, asociaciones y nuevos tratamientos
del síndrome de tracción vitreomacular en la actualidad.

Texto completo:



Reese AB, Jones IS, Cooper WC. Vitreomacular traction syndrome confi rmed histologically. Am J Ophthalmol 1970;69:975-977.

Chen TC, Cense B, Pierce MC, et al. Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imaging. Arch Ophthalmol 2005;123:1715-1720.

McDonald HR, Johnson RN, Schatz H. Surgical results in the vitreomacular traction syndrome. Ophthalmology 1994;101:1397-1402.

Shechtman DL, Dunbar MT. Th e expanding spectrum of vitreomacular traction. Optometry 2009;80:681-687.

Johnson MW. Posterior vitreous detachment: evolution and complications of its early stages. Am J Ophthalmol 2010;149:371-382.

Foos RY, Wheeler NC. Vitreoretinal juncture. Synchysis senilis and posterior vitreous detachment. Ophthalmology 1982;89:1502-1512.

Chuo JY, Lee TY, Hollands H, et al. Risk factors for posterior vitreous detachment: a case-control study. Am J Ophthalmol. 2006;142:931-937.

Sebag J. Anomalous posterior vitreous detachment: a unifying concept in vitreo-retinal disease. Graefes Arch Clin Exp Ophthalmol. 2004;242:690-698.

Simpson A, Petrarca R, Jackson TL. Vitreomacular adhesion and neovascular age-related macular degeneration: a review. Surv Ophthalmol 2012;57:498-509.

Johnson MW. Posterior vitreous detachment: evolution and role in macular disease. Retina 2012;32:S174-178.

Duker JS, Kaiser PK, Binder S, et al. Th e international vitreomacular traction study group classifi cation of vitreomacular adhesion, traction, and macular hole. Ophthalmology 2013;120:2611-2619.

Shao L, Xu L, You QS, et al. Prevalence and associations of incomplete posterior vitreous detachment in adult Chinese: The Beijing Eye Study. PloS one 2013;8:e58498.

Jackson TL, Nicod E, Simpson A, et al. Symptomatic vitreomacular adhesion. Retina 2013;33:1503-1511.

Chang LK, Fine HF, Spaide RF, et al. Ultrastructural correlation of spectral-domain optical coherence tomographic findings in vitreomacular traction syndrome. Am J Ophthalmol 2008;146:121-127.

Wu L, Zas M, Berrocal MH, et al. Anatomical and functional outcomes of symptomatic idiopathic vitreomacular traction. A Natural History Study From the Pan American Collaborative Retina Study Group. Retina 2016;36:1913-8.

Stalmans P, Duker JS, Kaiser PK, et al. OCT based interpretation of the vitreomacular interface and indications for pharmacologic vitreolysis. Retina 2013;33:2003-2011.

Barak Y, Ihnen MA, Schaal S. Spectral domain optical coherence tomography in the diagnosis and management of vitreoretinal interface pathologies. J Ophthalmol 2012;2012:876472.

Goldmann H. Senile changes of the lens and the vitreous: the Arthur J. Bedell lecture. Am J Ophthalmol 1964;57:1-13.

Johnson MW. Posterior vitreous detachment: evolution and complications of its early stages. Am J Ophthalmol 2010;149:371-382.

Sebag J. Anatomy and pathology of the vitreo-retinal interface. Eye 1992;6:541-552.

Johnson MW. Tractional cystoid macular edema: a subtle variant of the vitreomacular traction syndrome. Am J Ophthalmol 2005;140:184-192.

Spaide RF. Vitreomacular traction syndrome. Retina 2012;32:S187-S190

Sebag J. Vitreoschisis. Graefes Arch Clin Exp Ophthalmol 2008;246:329-332.

Smiddy WE, Green WR, Michels RG, et al. Ultrastructural studies of vitreomacular traction syndrome. Am J Ophthalmol 1989;107:177-185.

Bottós J, Elizalde J, Arevalo JF, et al. Vitreomacular Traction Syndrome, J Ophthalmic Vis Res 2012;7:148-161.

Ip MS, Baker BJ, Duker JS, et al. Anatomical outcomes of surgery for idiopathic macular hole as determined by optical coherence tomography. Arch Ophthalmol 2002;120:29-35.

Ullrich S, Haritoglou C, Gass C, et al. Macular hole size as a prognostic factor in macular hole surgery. Br J Ophthalmol 2002;86:390-393.

Gass JD. Reappraisal of biomicroscopic classifi cation of stages of development of a macular hole. Am J Ophthalmol 1995;119:752-759.

Stalmans P, Benz MS, Gandorfer A, et al MIVI-TRUST Study Group. Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes. N Engl J Med 2012;367:606-615.

Trese MT, Williams GA, Hartzer MK. A new approach to stage 3 macular holes. Ophthalmology 2000;107:1607-1611.

Chang S. Controversies regarding internal limiting membrane peeling in idiopathic epiretinal membrane and macular hole. Retina 2012;32:S200-S204.

Arevalo JF, Sanchez JG, Costa RA, et al. Optical coherence tomography characteristics of full-thickness traumatic macular holes. Eye 2008;22:1436–1441.

Singh AJ, Muqit MM, Woon WH. Is axial length a risk factor for idiopathic macular hole formation?. Int Ophthalmol 2012;32:393-396.

Shukla D, Naresh KB, Rajendran A, et al. Macular hole secondary to X-linked retinoschisis. Eye 2006;20:1459-1461.

Shukla D. Evolution and management of macular hole secondary to type 2 idiopathic macular telangiectasia. Eye 2011;25:532-533.

Sagara N, Kawaji T, Koshiyama Y, et al. Macular hole formation aft er macular haemorrhage associated with ruptura of retinal arterial macroaneurysm. Br J Ophthalmol 2009;93:1337-1340.

Van Newkirk MR, Johnson MW, Hughes JR, et al. B-scan ultrasonographic fi ndings in the stages of idiopathic macular hole. Trans Am Ophthalmol Soc 2000;98:163-169.

Witkin AJ, Patron ME, Castro LC, et al. Anatomic and visual outcomes of vitrectomy for vitreomacular traction syndrome. Ophthalmic Surg Lasers Imaging 2010;41:425-431.

Yamada N, Kishi S. Tomographic features and surgical outcomes of vitreomacular traction syndrome. Am J Ophthalmol 2005;139:112-117.

Koizumi H, Spaide RF, Fisher YL, et al. Th ree-dimensional evaluation of vitreomacular traction and epiretinal membrane using spectral-domain optical coherence tomography. Am J Ophthalmol 2008;145:509-517.

Hikichi T, Akiba J, Trempe CL. Eff ect of the vitreous on the prognosis of full-thickness idiopathic macular hole. Am J Ophthalmol 1993;116:273-278.

John V, Flynn H, Smiddy W, et al. Clinical course of vitreomacular adhesion managed by initial observation. Retina 2014;34:442-446.

Kusaka S, Saito Y, Okada AA, et al. Optical coherence tomography in spontaneously resolving vitreomacular traction syndrome. Ophthalmology 2001;215:139-141.

Sulkes DJ, Ip MS, Baumal CR, et al. Spontaneous resolution of vitreomacular traction documented by optical coherence tomography. Arch Ophthalmol 2000;118:286-287.

Hikichi T, Yoshida A, Akiba J, et al. Natural outcomes of stage 1, 2, 3, and 4 idiopathic macular holes. Br J Ophthalmol 1995;79:517-520.

Spaide RF, Wong D, Fisher Y, et al. Correlation of vitreous attachment and foveal deformation in early macular hole states. Am J Ophthalmol 2002;133:226-229.

Sonmez K, Capone A Jr, Trese MT, et al. Vitreomacular traction syndrome: impact of anatomical confi guration on anatomical and visual outcomes. Retina 2008;28:1207–1214.

Theodossiadis G, Grigoropoulos V, Th eodoropoulou S, et al. Spontaneous Resolution of Vitreomacular Traction Demonstrated by Spectral-Domain Optical Coherence Tomography. Am J Ophthalmol 2014;157:842-851.

Almeida D, Chin E, Rahim K, et al. Factors associated with spontaneous release of vitreomacular traction. Retina 2015;35:492-497.

Tzu JH, John VJ, Flynn HW Jr, et al. Clinical course of vitreomacular traction managed initially by observation. Ophthalmic Surg Lasers Imaging. Retina 2015;46:571-576.

Theodossiadis GP, Chatziralli IP, Sergentanis TN, et al. Evolution of vitreomacular adhesion to acute vitreofoveal separation with special emphasis on a traction-induced foveal pathology. A prospective study of spectral-domain optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 2015;253:1425-1435.

Wollensak G, Spoerl E, Grosse G, et al. Biomechanical signifi cance of the human internal limiting lamina. Retina 2006;26:965-968.

Farah ME, Maia M, Rodrigues EB. Dyes in ocular surgery: principles for use in chromovitrectomy. Am J Ophthalmol 2009;148:332-340.

Smiddy WE, Michels RG, Glaser BM, et al. Vitrectomy for macular traction caused by incomplete vitreous separation. Arch Ophthalmol 1988;106:624-628.

Melberg NS, Williams DF, Balles MW, et al. Vitrectomy for vitreomacular traction syndrome with macular detachment. Retina 1995;15:192-197.

Wu Y, Zhu W, Xu D, et al. Indocyanine green-assisted internal limiting membrane peeling in macular hole surgery: a metaanalysis. PloS One 2012;7:e48405

Chung E, Lew Y, Lee H, et al. OCT-guided Hyaloid Release for Vitreomacular Traction Syndrome, Kor J Ophthalmol 2008;22:169-173.

Greven M, Garg S, Chiu B, et al. Vitrectomy after ocriplasminfor vitreOmacular adhesion or macular hole (VAVOOM) study. Br J Ophthalmol 2016;100:1211-5.

Liotta LA, Goldfarb RH, Brundage R, et al. Eff ect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane. Cancer Res 1981;41:4629-4636.

Russell SR, Shepherd JD, Hageman GS. Distribution of glycoconjugates in the human retinal internal limiting membrane. Invest Ophthalmol Vis Sci 1991;32:1986-1995.

Schneider EW, Johnson MW. Emerging nonsurgical methods for the treatment of vitreomacular adhesion: a review. Clin. Ophthalmol 2011;5:1151-1165.

Smet MD, Gandorfer A, Stalmans P, et al. Microplasmin intravitreal administration in patients with vitreomacular traction scheduled for vitrectomy: the MIVI I trial. Ophthalmology 2009;116:1349-1355.

Stalmans P, Delaey C, de Smet MD, et al. Intravitreal injection of microplasmin for treatment of vitreomacular adhesion: results of a prospective, randomized, sham-controlled phase II trial (the MIVI-IIT trial). Retina 2010;30:1122-1127.

Haller J, Stalmans P, Benz MS, et al. MIVI-TRUST Study Group. Effi cacy of Intravitreal Ocriplasmin for Treatment of Vitreomacular Adhesion: Subgroup Analyses from Two Randomized Trials, Ophthalmology 2015;122:117-122

Song SJ, Smiddy W. Ocriplasmin for symptomatic vitreomacular adhesion: an evidence-based review of its potential. Core Evidence 2014:9:51-9.

Stefanini F, Maia M, Falabella P, et al. Profi le of ocriplasmin and its potential in the treatment of vitreomacular adhesión, Clin Ophthalmol 2014:8;847-856.

Haller JA, Stalmans P, Bnez MS, et al. Effi cacy of intravitreal ocriplasmin for treatment of vitreomacular adhesion: subgroup analyses from two randomized trials. Ophthalmology 2015;122:117-122.

Tyler L, Singer M, Bell D. Long-term outcomes in patients with vitreomacular traction treated with a single intravitreal injection of ocriplasmin. Retin Cases Brief Rep 2017;11:34-37.

Stalmans P, Duker J, Kaiser P, et al. OCT-based interpretation of the vitreomacular interface and indications for pharmacologic vitreolysis, Retina 2013;33:2003-2011.

Tibbetts M, Reichel E, Witkin A, Vision Loss Aft er Intravitreal Ocriplasmin Correlation of Spectral-Domain Optical Coherence Tomography and Electroretinography, JAMA Ophthalmol 2014;132:487-490.

Kim JE. Safety and complications of ocriplasmin: ocriplasmin, ocriplasmin; oh, how safe art thou? JAMA Ophthalmol 2014;132:379-380.

Johnson MW, Fahim AT, Rao RC. Acute ocriplasmin retinopathy. Retina 2015;35:1055-1058.

Chan CK, Wessels IF, Friedrichsen EJ. Treatment of idiopathic macular holes by induced posterior vitreous detachment. Ophthalmology 1995;102:757–767

Chan CK, Crosson JN, Mein CE, et al. Pneumatic vitreolysis for relief of vitreomacular traction. Retina 2017;37:1820-1831.

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